M8-B Hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

M8-B Hydrochronide 是一种选择性瞬时受体电位 melastatin-8 (TRPM8) 通道拮抗剂。M8 B，一种 TRPM8 拮抗剂。

M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist.M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures.

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Animal Model:Trpm8+/+ rats and mice Dosage:6 mg/kg Administration:I.v. or i.p.Result:Decreased deep body temperature (T(b)) in Trpm8+/+ rats and mice, but not in Trpm8?/? mice.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

TRPM8

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883976-12-3

432.96

C22H25ClN2O3S?

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (577.42 mM)

Cl.COc1cc(CN(CCN)C(=O)c2cccs2)ccc1OCc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years